Type1 Diabetes Mellitus (T1D) affects an estimated ~150,000 youth in the U.S., with ~18,000 youth diagnosed annually, yet much remains unknown about the clinical, developmental, and environmental effects of T1D on neurocognitive function. This proposal will establish a clinical research center to evaluate the neurocognitive and neural complications of pediatric T1D and identify potential risks and protective factors that affect brain and cognitive development trajectories in children with a first-time diagnosis of T1D. The project, a collaboration between the Psychiatry, Pediatrics, Endocrine and Allied Health Sciences Departments and funded as a consortium across 10 US Diabetes Research Centers, will further develop a clinical research infrastructure to recruit and retain children and families with T1D through stakeholder engagement and effective dissemination, and will develop predictive models integrating multimodal brain, behavior and clinical data to assist in risk stratification and development of effective targeted early interventions and clinical care practices. (Not open for Recruitment yet)