Anhedonia (ANH), the reduced ability to anticipate or experience pleasure, is a major transdiagnostic contributor to disability, inferior quality of life, and a core characteristic of multiple severe psychopathologies. ANH emerges in adolescence prior to the onset of these disorders and is highly prevalent (up to 20%) in youth 13-15 years. However, ANH in adolescence is poorly understood and interventions remain few. A growing body of evidence suggests that stress exacerbates ANH and dysregulated acute stress response mechanisms may critically contribute to ANH. Yet, little is known about the role of stress neurobiology in the emergence, course, and severity of ANH in adolescence, a critical developmental period marked by significant pubertal changes and steep maturation of neural circuits implicated in the recalibration of the stress-response systems and mood regulation.