PASS Study

The focus of the Pathways to Adolescent Success Study (PASS) is on anxiety and adolescent development to better understand how the brain, behavior, and lifestyle of adolescents with symptoms of anxiety develop over time. Our ultimate goal is to learn how to develop more effective treatments that are more personalized based on the brain, stress physiology, and social factors for individual adolescents.

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STAaRS Study

STAaRS focuses on understanding the biological mechanisms of acute stress response in adolescents with anhedonia (ANH), a condition marked by reduced ability to experience pleasure and linked to severe psychopathologies. The research aims to explore how multi-system stress responses, integrating both physiological and neural factors, contribute to the severity and course of ANH during adolescence—a critical developmental period.

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ProNET Study

The Prodromal Network Outcomes project (ProNET) aims to address the urgent need for preventing psychotic disorders in Clinical High Risk (CHR) patients by thoroughly phenotyping 1,040 individuals across 26 international sites. Utilizing multi-modal biomarkers, including MRI, EEG, genetics, and digital phenotyping, the study seeks to map these onto clinical outcomes over 24 months.

T1D Study

Type1 Diabetes Mellitus (T1D) affects an estimated ~150,000 youth in the U.S., with ~18,000 youth diagnosed annually, yet much remains unknown about the clinical, developmental, and environmental effects of T1D on neurocognitive function. This proposal will establish a clinical research center to evaluate the neurocognitive and neural complications of pediatric T1D and identify potential risks and protective factors that affect brain and cognitive development trajectories in children with a first-time diagnosis of T1D. The project, a collaboration between the Psychiatry, Pediatrics, Endocrine and Allied Health Sciences Departments and funded as a consortium across 10 US Diabetes Research Centers, will further develop a clinical research infrastructure to recruit and retain children and families with T1D through stakeholder engagement and effective dissemination, and will develop predictive models integrating multimodal brain, behavior and clinical data to assist in risk stratification and development of effective targeted early interventions and clinical care practices.

NCTRACS Translational Science Pilot Study

The study focuses on developing an Integrated Digital Health Platform (DHP) to better assess and respond to mental health crises in adolescents. The research aims to bridge existing gaps by integrating real-time biological, psychosocial, and environmental signals to understand psychological well-being and deliver targeted interventions. The platform utilizes wearable health monitoring devices and ecological momentary assessments to capture real-time data, enhancing self-regulation through context-specific interventions. Funded by TRACS, the study has two main objectives: developing a bidirectional sensor network to track stress indicators and testing the system in lab settings to ensure reliable sensor-app communication.